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Microtubules are one of three principal components of the cytoskeleton. A microtubule is composed of tubulin dimers, consisting of two closely related polypeptides called α- and β-tubulin. Tubulin dimers polymerize into protofilaments assembled around a hollow core. Tubulin dimers polymerize at the plus end of a microtubule. The polymerized tubulin dimers form a sheet that zips up into the mature microtubule just behind the region of growth. The tubulin dimers that add to the microtubule are bou
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SOLVED:The lifetime of a microtubule in a mammalian cell, between its formation by polymerization and its spontaneous disappearance by depolymerization, varies with the stage of the cell cycle. For an actively proliferating cell, the average lifetime is 5 minutes in interphase and 15 seconds in mitosis. If the average length of a microtubule in interphase is 20 μm, how long will it be during mitosis, assuming that the rates of microtubule elongation due to the addition of tubulin subunits in the
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