A team of chemists at the Korea Advanced Institute of Science and Technology has succeeded in pulling an oxygen atom from a molecule and replacing it with a nitrogen atom. In their study, published in ...

Heterocycles, molecular rings found in many pharmaceuticals, have a reputation for stubbornly resisting modification. That is, in a heterocycle, heteroatoms of one type aren’t easily swapped for ...

Researchers at the University of Oklahoma have developed a breakthrough method of adding a single nitrogen atom to molecules, unlocking new possibilities in drug research and development. Now ...

Together, the two methods should enable medicinal chemists to make these single-atom substitutions in a swath of common molecules, easing efforts to generate analogues of drug candidates. “This is the ...

One small atom can make a big difference in a molecule’s pharmacological properties. Especially if that atom is a nitrogen. Chemists at the University of Oklahoma have now unveiled a new strategy for ...

Chemists offer two new methods to develop a way to easily replace a carbon atom with a nitrogen atom in a molecule. The findings could make it easier to develop new drugs. For years, if you asked the ...

An unconventional route for modifying pharmaceutically relevant molecules swaps an atom of carbon for one of nitrogen. The resulting derivatives might open up avenues of research in ...

Tiny changes at the atomic scale can determine the future of clean energy. In a new study, Tohoku University researchers have revealed how the precise coordination environment surrounding a single ...

For years, if you asked the people working to create new pharmaceutical drugs what they wished for, at the top of their lists would be a way to easily replace a carbon atom with a nitrogen atom in a ...