Researchers have identified a mechanism by which acetylcholine, a neurotransmitter best known for its role in muscle control and attention, can effectively commandeer serotonin release inside the ...

Expert Rev Neurother. 2012;12(11):1351-1365. With regard to understanding the disease process in AD, it is of considerable interest to consider the temporal relationship between the loss of ...

Karuna Therapeutics focuses on developing therapies that target muscarinic cholinergic receptors to treat psychosis and cognitive impairment in CNS disorders. The Company's lead asset, KarXT, has ...

Nicotine withdrawal induces behavioral symptoms such as tremors and shaking. Suppressing striatal cholinergic interneurons or administering the muscarinic antagonist Procyclidine significantly reduces ...